Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma
نویسندگان
چکیده
BACKGROUND The spectrum of Kaposi's sarcoma (KS) has been expanded to include pre-KS lesions. CASE PRESENTATION We report, for the first time, a case providing direct histological evidence of the development of early (in-situ) KS from mediastinal lymphatic vessels in the setting of chronic lymphedema in an HIV-positive patient. Spindle-shaped and endothelial cells in these early KS-appearing lesions were immunoreactive for HHV8, D2-40 and CD34. CONCLUSION Our findings suggest that HHV8-infected spindle-shaped cells associated with lymphangiogenesis that evolve into KS lesions, acquire from the outset an aberrant mixed vascular and lymphatic endothelial cell phenotype.
منابع مشابه
Morphologic and Immunophenotypic Evidence of In-Situ Kaposi’s Sarcoma Short Title: In-Situ Kaposi’s Sarcoma
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ورودعنوان ژورنال:
- BMC Clinical Pathology
دوره 6 شماره
صفحات -
تاریخ انتشار 2006